Getting your questions ready
Getting your questions ready
Beat the crowd
9 questions No timer
94 free Grey's Anatomy trivia questions with answers — entertainment quiz, new questions added Aug 2026.
71 free Grey's Anatomy trivia questions with answers. Are you a true Grey's Anatomy superfan? Put your knowledge of Grey Sloan Memorial Hospital to the test with our exciting trivia quiz. From memorable character moments to plot twists, discover how well you really know this beloved medical drama series.
30 of 94 questions with answers and explanations. Play the quiz
Q 01Who is the creator and executive producer of the television series Grey's Anatomy?
Shonda Rhimes
Shonda Rhimes created the hit medical drama Grey's Anatomy, as well as its spin-off series Private Practice and the political thriller Scandal.
Q 02Like her mother before her, Meredith Grey specialises in which branch of surgery on Grey's Anatomy?
General Surgery
General Surgery runs in the family: Ellis Grey was a legend in it, and Meredith rose to chief of general surgery and later chief of surgery.
Q 03Which Grey's Anatomy surgeon, nicknamed McDreamy, begins operations with 'It's a beautiful day to save lives'?
Derek Shepherd
Derek Shepherd's line became his good-luck ritual; Patrick Dempsey reused it in 2020 to encourage fans to wear masks.
Q 04Which original intern was diagnosed with Stage 4 metastatic melanoma?
Izzie Stevens
Izzie Stevens learned in Season 5 that she had Stage 4 melanoma with metastases in her skin, liver and brain; she was treated with surgery and IL-2 immunotherapy.
Q 05Which character left Seattle to work at the Mayo Clinic for a period before moving to Switzerland?
Cristina Yang
Cristina Yang briefly left Seattle to work at the Mayo Clinic after the plane crash, later moving to Zurich, Switzerland, to run a research hospital.
Q 06What is the nickname of Miranda Bailey's son, born during Season 2?
Tuck
Tuck: Bailey's son William George Bailey Jones, delivered in Season 2 with George O'Malley's help, is nicknamed Tuck after his father, Tucker Jones.
Q 07What neurological condition did Ellis Grey suffer from?
Alzheimer's Disease
Alzheimer's Disease, early-onset, meant Ellis rarely recognised her daughter; Meredith later had herself tested for the genetic markers.
Q 08Which character was the Head of Orthopedic Surgery at Grey Sloan Memorial Hospital?
Callie Torres
Dr. Callie Torres was a prominent orthopedic surgeon and eventually became the head of the orthopedic surgery department at Grey Sloan Memorial Hospital.
Q 09In which surgical specialty is Jackson Avery's mother, Catherine, renowned?
Urology
Urology: Catherine Avery, played by Debbie Allen, is a celebrated urologist who first arrives at Seattle Grace in Season 8 and later chairs the Avery Foundation.
Q 10Grey's Anatomy premiered on ABC as a mid-season replacement in which year?
2005
2005, on March 27, and it was only meant to fill a slot for a few weeks; it became ABC's longest-running scripted primetime series.
Q 11Which actor plays George O'Malley on Grey's Anatomy?
T.R. Knight
T.R. Knight played George O'Malley for the show's first five seasons and earned a 2007 Emmy nomination for the role.
Q 12Which actress plays Meredith's surgeon mother?
Kate Burton
Kate Burton, daughter of Richard Burton, played Ellis Grey from the pilot onward and earned two Emmy nominations for the role.
Q 13Which two doctors, both transfers from Mercy West, were killed in the Grey's Anatomy season 6 hospital shooting?
Reed Adamson and Charles Percy
Reed Adamson and Charles Percy, both Mercy West transfers, were shot dead during the Season 6 finale rampage; Derek Shepherd and Alex Karev were also hit but survived.
Q 21How did Izzie Stevens pay her way through medical school?
Modeling
Modeling: Izzie Stevens funded medical school with modeling work, including a Bethany Whisper lingerie campaign that Alex Karev plastered around the hospital in Season 1.
Q 22What was the original name of the hospital where the main events of Grey's Anatomy take place?
Seattle Grace Hospital
The hospital in Grey's Anatomy was originally named Seattle Grace Hospital before undergoing several name changes throughout the series, including Seattle Grace Mercy West and eventually Grey Sloan Memorial Hospital.
Q 23Who received Cristina Yang's hospital shares and board seat when she left Grey Sloan?
Alex Karev
Q 14Who was the Chief of Surgery at Seattle Grace Hospital when the series began?
Richard Webber
Richard Webber ran Seattle Grace as Chief of Surgery for years before the series began, and later stepped aside when Derek Shepherd was offered the job.
Q 15Which spin-off followed Addison Montgomery after she left Seattle for California?
Private Practice
Addison's move to a Los Angeles wellness practice launched Private Practice, which ran for six seasons from 2007 to 2013.
Q 16What happened to George O'Malley at the end of his intern year that made him retake it?
He failed his exam by one point
George O'Malley famously failed his intern exam, a rare occurrence among the main characters, and had to repeat his intern year.
Q 17Which surgeon did Callie Torres marry in the Season 7 episode 'White Wedding'?
Arizona Robbins
Arizona Robbins married Callie Torres in Season 7, with Miranda Bailey officiating, after Callie survived the car crash that nearly killed her and their unborn daughter Sofia.
Q 18Across the street from Seattle Grace, the doctors of Grey's Anatomy drink at the Emerald City Bar, better known by what name?
Joe's Bar
Joe's Bar takes its name from owner Joe, played by Steven W. Bailey; Meredith met Derek there the night before her first day as an intern.
Q 19Which surgeon has been married to both Cristina Yang and Teddy Altman?
Owen Hunt
Owen Hunt married Cristina Yang in Season 7 and, years after she left for Zurich, wed Teddy Altman, the mother of his daughter Allison.
Q 20What medical condition was Zola, Meredith and Derek's adopted daughter, born with?
Spina Bifida
Zola, who Meredith and Derek adopted from Malawi, was born with spina bifida and came to Seattle Grace for a shunt placement to address her condition.
Cristina handed her ownership stake and board seat to Alex Karev, her fellow original intern, before leaving for Switzerland at the end of Season 10.
Q 24Which character famously had a brain tumor that she initially kept a secret?
Amelia Shepherd
Amelia Shepherd faced a significant storyline where she discovered she had a brain tumor, which she kept hidden for a period.
Q 25What was Cristina Yang's primary surgical specialty?
Cardiothoracic Surgery
Cristina Yang was renowned for her exceptional talent and dedication to cardiothoracic surgery, becoming a world-class surgeon in that field.
Q 26Which actress plays Meredith Grey?
Ellen Pompeo
Ellen Pompeo has played Meredith Grey since the 2005 pilot and narrates the show; her 2018 contract of more than $20 million a year made her one of television's highest-paid actresses.
Q 27Who led the bomb squad that Meredith worked with in the Season 2 bomb scare?
Dylan Young
During a tense bomb scare in Season 2, Meredith worked closely with bomb squad leader Dylan Young, who ultimately died in the incident.
Q 28Which original intern famously died after being hit by a bus?
George O'Malley
George O'Malley tragically died after selflessly saving a woman from being hit by a bus, suffering severe injuries that left him unrecognizable.
Q 29What was Denny Duquette, Izzie Stevens's love interest, waiting for in the hospital?
A heart transplant
Denny spent months as a cardiac patient waiting for a donor heart; he finally received one, only to die of a stroke hours later, on the day he proposed to Izzie.
Q 30What nickname did Lexie Grey earn thanks to her eidetic memory?
Lexipedia
Lexie could recall anything she had read, which earned her the nickname 'Lexipedia' from her colleagues.