My Sister's Keeper Trivia
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50 free My Sister's Keeper trivia questions with answers — literature quiz, new questions added Aug 2026.
Jodi Picoult's story of the Fitzgerald family asks a question with no comfortable answer: can a child conceived to keep her sister alive ever say no? Anna's lawsuit against her own parents made the novel a book-club fixture, and the 2009 film brought the courtroom and the hospital ward to a far wider audience, though not without a famous row over how it should finish. These 50 questions cover the novel's plot and characters, the legal fight at its centre, the choices the film made with its cast and its conclusion, how Picoult came to write the book, and what critics and librarians made of it. It suits book clubs, English classes and anyone who read it in one sitting and still thinks about the last chapter. Play it on screen or print it for the table.
30 of 50 questions with answers and explanations. Play the quiz
Q 01What term describes Anna Fitzgerald, conceived through IVF in My Sister's Keeper?
A savior sibling
A savior sibling is conceived as a donor match for a sick child; Picoult has said the idea grew from news of a real American couple whose son was born as a match for his sister.
Q 02In Picoult's novel, what kills Anna Fitzgerald just after she wins her case?
A truck hitting the car
A truck hitting the car leaves Anna brain-dead, and lawyer Campbell Alexander approves the organ donation that saves Kate. The epilogue follows the family eight years on.
Q 03How does the 2009 film of My Sister's Keeper end for the two sisters, compared with Picoult's novel?
Kate dies and Anna lives
Kate dies and Anna lives in the film, the reverse of the novel, in which Anna is killed after the trial and her kidney saves Kate.
Q 04Which director of The Notebook and John Q. made the 2009 film My Sister's Keeper?
Nick Cassavetes
Nick Cassavetes is the son of director John Cassavetes and actress Gena Rowlands, and he cast his mother as the older Allie in The Notebook.
Q 05Jodi Picoult has said she regretted letting the director of My Sister's Keeper do what?
Change the ending
Change the ending is what Picoult said she regretted allowing; she had defended her own ending as the only one true to the story, even after phoning an oncology nurse to ask for another way out.
Q 06Which There's Something About Mary star plays the mother, Sara Fitzgerald, in the 2009 adaptation?
Cameron Diaz
Cameron Diaz's Sara is a former attorney who gave up her career to care for Kate, and she goes back to work only when the family's ordeal is over.
Q 07Which Little Miss Sunshine Oscar nominee plays Anna Fitzgerald in the 2009 adaptation?
Abigail Breslin
Abigail Breslin was Oscar-nominated at ten for Little Miss Sunshine, and she came to this film as a late replacement after its first Anna withdrew.
Q 08Which sister act was cast as Kate and Anna Fitzgerald before the elder balked at shaving her head?
Dakota and Elle Fanning
Dakota and Elle Fanning withdrew together in February 2008, and the actress who took over as Kate went through with it, shaving her head and her eyebrows.
Q 09Anna Fitzgerald hires lawyer Campbell Alexander to sue her parents for what legal status?
Medical emancipation
Medical emancipation would let Anna make her own treatment decisions, including whether to give Kate a kidney; when she wins, the judge hands Campbell medical power of attorney.
Q 10Under cross-examination in the 2009 adaptation, what does Anna Fitzgerald admit about her lawsuit?
Kate asked her to refuse
Kate asked her to refuse the kidney, knowing she would not survive another operation and having had enough of the family's suffering; Jesse's intervention at the hearing forces the admission.
Q 11Jodi Picoult set the Fitzgeralds' story in the fictional town of Upper Darby, in which US state?
Rhode Island
Rhode Island is the novel's setting, but the film moved the Fitzgeralds west and was shot in Southern California.
Q 12What is the full first name of Anna Fitzgerald, the youngest Fitzgerald child in Picoult's novel?
Andromeda
Andromeda is the name of a galaxy and a constellation, a fitting choice from a father who is fond of astronomy; everyone just calls her Anna.
Q 13Why does lawyer Campbell Alexander secretly need his service dog in Picoult's novel?
He has epilepsy
He has epilepsy, developed after a concussion, and it is why he left Julia Romano years earlier, believing she deserved better; a seizure during the trial exposes the secret.
Q 21Which actress, Ariel DuBois on the TV series Medium, plays Kate Fitzgerald in the 2009 adaptation?
Sofia Vassilieva
Sofia Vassilieva shaved her head and her eyebrows to play Kate, and became an honorary ambassador for Stand Up to Cancer the same year.
Q 22Which 30 Rock star plays Anna's lawyer, Campbell Alexander, in the 2009 film My Sister's Keeper?
Alec Baldwin
Alec Baldwin won two Emmys as Jack Donaghy, and his Campbell, a lawyer who keeps a service dog he will not explain, supplies the film's dry comic relief.
Q 23Which twice Oscar-nominated actress, for Working Girl and In & Out, plays Judge De Salvo on screen?
Joan Cusack
Q 14Julia Romano, Campbell Alexander's high-school girlfriend, is appointed to Anna's case in what role?
Guardian ad litem
A guardian ad litem advises the court on what is best for a child, which puts Julia opposite the man who broke her heart in high school without ever saying why.
Q 15What loss shapes Judge DeSalvo, who hears Anna's case in Picoult's novel?
His daughter, to a drunk driver
His daughter, to a drunk driver, when she was 12, so he too is a parent who has buried a child by the time Anna's petition reaches his court.
Q 16Sara Fitzgerald, once a civil attorney, responds to Anna's lawsuit in Picoult's novel by doing what?
Representing herself
Representing herself, Sara at first assumes Anna merely wants attention and expects the complaint to be withdrawn; Anna will not back down.
Q 17Jesse Fitzgerald, the overlooked eldest child, spends his time in Picoult's novel doing what?
Setting fires in empty buildings
Setting fires in empty buildings with homemade explosives, and using drugs, is how Jesse acts out after years of being ignored in favour of Kate and Anna; the epilogue makes him a police officer.
Q 18In the epilogue of Picoult's novel, eight years after the trial, what has Kate Fitzgerald become?
A ballet teacher
A ballet teacher, Kate also narrates the final pages, speaking of deep guilt and of a bond with the part of Anna she carries inside her.
Q 19In Picoult's novel, what does Sara hide from Kate about Taylor Ambrose, the boyfriend she met during chemotherapy?
That he has died
That he has died is hidden by Sara, who fears the grief would rob Kate of her will to live; Kate assumes Taylor simply stopped calling, and the rift with her mother deepens when she learns the truth.
Q 20How is wealthy aunt Suzanne, who openly criticises Sara's treatment of both girls, related to Sara?
Her older sister
Her older sister by ten years, Suzanne climbed the corporate ladder while Sara gave up the law for motherhood, and she backs Anna more openly than Brian does.
Joan Cusack later won a Primetime Emmy for playing Sheila Jackson on Shameless; the novel's Judge De Salvo is a man, while the film's is Judge Joan De Salvo.
Q 24Which star of The Lost Boys and Speed 2 plays the father, Brian Fitzgerald, in the 2009 adaptation?
Jason Patric
Jason Patric, grandson of Jackie Gleason, plays the parent with misgivings: Brian takes Anna's lawsuit far better than Sara does.
Q 25Which Sarah Connor Chronicles star plays Kate Fitzgerald's boyfriend, Taylor Ambrose, on screen?
Thomas Dekker
Thomas Dekker played John Connor on that series and Zach on Heroes; in the film, Taylor is a fellow patient whom Kate meets in hospital and falls for.
Q 26Which Bones star plays Dr. Farquad, one of Kate Fitzgerald's doctors, in the 2009 adaptation?
Emily Deschanel
Emily Deschanel's father, Caleb Deschanel, shot the film as its cinematographer; her younger sister is the actress and singer Zooey Deschanel.
Q 27Which film topped the US box office the weekend My Sister's Keeper opened fifth, in June 2009?
Revenge of the Fallen
Revenge of the Fallen, the Transformers sequel, opened that weekend with over $100 million; Variety had tipped Keeper as a female-friendly alternative to it.
Q 28Which Randy Newman song, sung by Edwina Hayes, opens the My Sister's Keeper soundtrack album?
Feels Like Home
Feels Like Home was written for Randy Newman's Faust, in which Bonnie Raitt sang it; Hayes's cover came from her 2008 album Pour Me a Drink.
Q 29Which Bridge to Terabithia and The Proposal composer also scored the 2009 film My Sister's Keeper?
Aaron Zigman
Aaron Zigman wrote his first film score for the same director's John Q. in 2002 and stayed with him for The Notebook before this film.
Q 30My Sister's Keeper's director drew on his child Sasha's health history; she was born with what?
A heart defect
A heart defect that required substantial surgery; he had already dedicated his 2002 film John Q. to Sasha.